My one rear speaker is much further away from the other and even after compensating with the amp's volume and distance/delay settings, it can still appear quite noticable at times. It can really depend on what you are playing, and be quite off-putting at times.
I would suggest you try to overcome this further by compensating with the distance between the fronts, as I have found that having the one rear speaker further away and at a different angle from the fronts can worsen the effect. You might also find that having the rears quite high up the walls and pointed down and toed in a little, rather than at ear height, will make things better.
Are you interested in SACD? Although most amps allow you to adjust the rear right and left settings separately, this isn't going to help for SACD requiring multi-channel output since you would need to use the player's settings for this. Some SACD players only allow you to set both rear speakers together. Also, some people will tell you that SACD sounds a lot better with all speakers at ear height.
In short, you can overcome some of the problems but not having the rears at equal distances will still be a compromise, at times at least. If you are mainly interested in movies then you might want to consider bipoles or dipoles, to make the sound from the rear speakers less localised and thus reduce the effect of unequal distances.