Look, anything will work more or less. It's just how well it will work.
Having one surround speaker so close and the other so far away won't produce a particularly good sound.
If it were me, I'd get rid of the fireplace and put your screen bang opposite the main seat.
Actually if it were me I would move walls and doors to get the best experience.
I doubt either are going to be an option for you.
It's *always* a matter of compromise when it comes to the sound. Even in a dedicated home cinema.