So, my guesses...
New Splatoon trailer
Mariokart 8 DLC pack 2 details
Kirby Cursed Canvas trailer
Smash Bros - Mewtwo and Miiverse stage available straight after the Direct
SNES Remix
More details on the English version of Xenoblade Chronicles X, maybe launch period announced too
Fire Emblem IF trailer
Devils Third update
Teaser for the next Retro Studios game
English release date for Etrian Odyssey 5 or SOMETHING about SMT V FE (Atlus retweeted the Nintendo Direct announcement)
Indie video roll
What I'd love to see...
Extra stages DLC for Smash Bros (64 pack, Melee pack, Brawl pack please)
Monster Hunter 4 HD for Wii U
Whatever AAA game Tantalus/Straight Right were porting to Wii U (apparently the biggest project in their history - I say it's either GTA V or Dragon Age
)
Some news on Camelot's new project (it's either a Mario Golf/Tennis for Wii U, or Golden Sun for 3DS)