Monoclonal antibody therapy

[SteveAWOL]

Currently undergoing Phase 3 trials in USA, Dr Fauci and the former head of ObamaCare both expect monoclonal antibody therapy to be ready in time for winter which should bridge the gap for vulnerable groups until vaccines are deployed.

Fauci expects results from clinical trial for COVID treatment by fall

Anthony Fauci discusses the need for monoclonal antibodies, proteins that could fight the coronavirus at multiple stages, in a Facebook Live interview

www.latimes.com

Antibody therapies could be a bridge to a coronavirus vaccine — but will the world benefit?

Monoclonal antibodies are complex and expensive to produce, meaning poor countries might be priced out.

www.nature.com

 

[IronGiant]

I haven't looked into it recently, but my understanding was this technology isn't cheap?

 

[acatweasel]

I haven't looked into it recently, but my understanding was this technology isn't cheap?

Probably not, but it’s going to get cheaper when we make x million of them!!

It’s all good stuff. I’m still trying to work out why it’s easier to make an artificial antibody to a viral protein, rather than inject the isolated viral protein into you as a method of getting your immune system to do the work. I’m not going to worry about it too much, as these lads are very obviously much brighter than I.

Just had a read of how these things can be used to carry radioactive substances as a targeted attack against tumours. Clever stuff, combining targeted immunology with radiotherapy.

 

[richp007]

More bedtime reading!! Thanks @SteveAWOL

 

[simonblue]

Thanks Steve,any news on a treatment is good at the moment

 

[SteveAWOL]

Coronavirus: Monoclonal antibodies to begin UK trial

Laboratory-made antibodies are to be trialled on 2,000 people with coronavirus in UK hospitals.

www.bbc.co.uk

RECOVERY COVID-19 Phase 3 Trial to Evaluate Regeneron's REGN-COV2 Investigational Antibody Cocktail in the UK | Regeneron Pharmaceuticals Inc.

TARRYTOWN, N.Y. and OXFORD, England, Sept. 14, 2020 /PRNewswire/ -- One of the world's largest efforts to find effective COVID-19 treatments will evaluate the impact of REGN-COV2 on mortality, hospital stays, and the need for ventilation Regeneron Pharmaceuticals, Inc.

investor.regeneron.com

 

[SteveAWOL]

Science | AAAS

www.sciencemag.org

 

[SteveAWOL]

Reuters | Breaking International News & Views

Find latest news from every corner of the globe at Reuters.com, your online source for breaking international news coverage.

uk.reuters.com

 

[SteveAWOL]

 

[SteveAWOL]

As posted by @Trollslayer in the main thread

Covid: Jab for people who cannot be vaccinated trialled

An injection of antibodies might provide up to six months' protection to immuno-compromised patients.

www.bbc.co.uk

Here’s some more info about AZD7442 for those who want a deep dive

COVID-19 Long-Acting AntiBody (LAAB) combination AZD7442 rapidly advances into Phase III clinical trials

www.astrazeneca.com

 

[Trollslayer]

I am at the paddling stage I'm afraid.

 

[SteveAWOL]

Germany to use new antibody-based coronavirus drug – DW – 01/24/2021

Health Minister Jens Spahn has said the government has purchased a new drug to help fight COVID-19 amid a vaccine shortage. Germany will be the first EU nation to use the medicine, which was also given to Donald Trump.

www.dw.com

 

[Trollslayer]

We need every option.

 

[SteveAWOL]

RECOVERY trial Regeneron’s monoclonal antibody combination reduces deaths for hospitalised COVID-19 patients | University of Oxford

The Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial has demonstrated that the investigational antibody combination developed by Regeneron reduces the risk of death when given to patients hospitalised with severe COVID-19 who have not mounted a natural antibody response of their own.

www.ox.ac.uk

 

[SteveAWOL]

Professor Doherty seems enthusiastic about Australia ordering in Sotrovimab doses.

The Nobel Prize in Physiology or Medicine 1996

The Nobel Prize in Physiology or Medicine 1996 was awarded jointly to Peter C. Doherty and Rolf M. Zinkernagel "for their discoveries concerning the specificity of the cell mediated immune defence"

www.nobelprize.org

 

[SteveAWOL]

Peter Horby

FMedSci Peter Horby - Moh Family Foundation Professor of Emerging Infections and Global Health

www.ndm.ox.ac.uk

 

[Trollslayer]

 

[SteveAWOL]

Martin Landray

FMedSci Martin Landray - Professor of Medicine and Epidemiology

www.ndph.ox.ac.uk

 

[SteveAWOL]

Nanobodies (aka single-domain antibodies) are in a similar vein, so thought this might be most appropriate thread…

Covid: Immune therapy from llamas shows promise

An immune therapy derived from llama blood shows "exciting potential" in early coronavirus trials.

www.bbc.co.uk

 

[Trollslayer]

At the start I was slightly allamad but then it began to make sense.

Seriously, thank you for that.

 

[SteveAWOL]

UK approves another antibody treatment for Covid

It's called sotrovimab and should cut the risk of severe illness, even for new variants such as Omicron, say scientists.

www.bbc.com

 

[Dave1979]

I haven't looked into it recently, but my understanding was this technology isn't cheap?

I get it for MS and I thinks it’s about £100k a year!

 

[SteveAWOL]

EU regulator builds Omicron defences with approvals of GSK-Vir, Sobi drugs

The European Union's drug regulator on Thursday approved a COVID-19 treatment from British-U.S. duo GSK and Vir Biotechnology and another from Swedish drugmaker Sobi , as the bloc builds its defences against Omicron.

www.reuters.com

 

[SteveAWOL]

BBC Four - Royal Institution Christmas Lectures, 2021, Fighting Back

Jonathan Van-Tam unlocks the science of vaccines, variants and viral genetic codes.

www.bbc.co.uk