Provided you lay the sub on something soft to protect the finish I can't see a problem. The driver (loudspeaker) cone must be free to move and should not be placed too close to a wall or solid furniture. If the sub has a port (open pipe) that should not be blocked either. If the sub is an active type then the amplifier controls should be made reasonably accessible and able to have air circulating around it should it become warm in use. I doubt you'll hear any difference in performance with most subs.