Should work on a keyboard at anyone time. I play FPS games and ive been having problems with keys not working when pressed. What ive put this down to is pressing more than 2 keys at once. I.E If i am pressing Up arrow and right arrow at the same time for movement, then i cannot use any other key, to select a weapon/use an item? I have a USB mouse plugged into a USB 3 port and i am using a (Razor Lycosa keyboard) I have never had this problem on PS2 keyboards in the past.