That's around 20Gb of unused, unwanted files that will slow down the average PC, increase file fragmentation and the user experience when using browsers etc. This is just a month's worth.
Most of that isn't unused.
The recycle bin we're all familiar with and if you don't want it to store 18GB worth of deleted files you can simply right click it, open properties and change the size.
Cookies and cache are both part of the normal function of a web browser. Deleting the cache files will cause it to take longer to load web pages as it has to redownload the images rather than loading them from the cache and deleting the cookies will cause websites to loose set preferences and require you to log in again.
Cookies expire after a set time and get deleted and cache has an upper disk space limit where old stuff is deleted to make room for the new. Most browsers offer you the ability to disable cookies and many let you set the size of their cache.
Prefetch data is a cache for windows use to help speed up the loading of programs. IIRC it's got a limited number of entries and the oldest ones get deleted by the OS when a slot is required for newer ones.
So the only genuinely unused files in your list are 12 memory dumps, 50 log files and 86 error reports. And CCleaner may be counting logs that will be re-created immediately as they're overwritten every time the OS or a program runs.
The log files and error reports take up hardly any space at all. Memory dumps are created in fairly serious system crashes, blue screens and similar, which are fairly rare these days. I believe Windows only stores one big (kernal) memory dump at a time, overwriting the old one, so that size will only grow by new Minidumps if she continues to experience the problems that cause them to be created.
I've checked my machine and there are no memory dump or minidump files after three years of use.
So there's maybe 300MB and a couple of hundred junk files. The rest are normal temporary files that are managed by their respective programs. The'll take up a certain maximum space and then grow no more.