Bournemouth 15:00 Everton
Wayne Rooney returns for Everton after missing two games due to illness, while James McCarthy is also available.
Chelsea 15:00 Stoke
Chelsea have no new injury concerns but Antonio Conte may rotate his squad with a trip to Arsenal to come on Wednesday.
Huddersfield 15:00 Burnley
Laurent Depoitre is vying for a recall, while Chris Lowe is in contention to recover from a foot problem. Burnley will be without defender Stephen Ward, who is missing for a fourth game due to a knee injury.
Liverpool 15:00 Leicester
Liverpool captain Jordan Henderson could be out until February with a hamstring injury.
Newcastle 15:00 Brighton
Newcastle goalkeeper Rob Elliot has been ruled out with a thigh injury. He joins Jesus Gamez, Florian Lejeune and Aleksandar Mitrovic on the sidelines, but Isaac Hayden returns after missing the last two matches.
Watford 15:00 Swansea
Watford head coach Marco Silva could welcome back Will Hughes, Miguel Britos and Isaac Success after injury. New Swansea manager Carlos Carvalhal could have Wilfried Bony back from a hamstring injury which has kept him out for two matches.
Man Utd 17:30 Southampton
Romelu Lukaku is likely to start despite Jose Mourinho admitting the Manchester United forward is "tired".