its very easy to remove dust from the 300 i had to do it straight away after i ceiling mounted it, it now hasnt returned after 70 hrs, i only had to clean my old 100 3 times in 3200 hrs, i copied this guide from the avs forums which explains how to do it
1. Find a dust-free location
2. Remove the AE300's filter for cleaning and get in and around the filter vent with a vacuum cleaner to clear any loose dust.
3. Unscrew the screws in the base of the AE-300.
4. Remove the lid.
5. Locate the LCD panel ribbon cables as seen
HERE
6. With the projector on it's side hold the can of air vertical (THIS IS IMPORTANT! ) and blow a few sharp bursts down either side of the ribbons where they go down into the optical path.
7. Replace the lid, replace the screws.
8. Re-mount the projector.
9. Job done.
The dust blobs have no re-occured in the last 200hrs viewing, so I think the lesson is to avoid disturbing the projector physically (ie run it for a month on a table then ceiling mount it) and be careful when cleaning the filter as this generates a fair bit of loose dust so make sure you suck it up before powering up the projector.
Note: If you are using a can of air make sure you keep it vertical or you'll get a projector full of propellant, and you probably don't want this