In contrast to the above....
That’s good news. I would suggest it is a matter of time before it becomes something that can evade current vaccines. But if we can get vaccines distributed fast enough, maybe we can “end its line” and eliminate the current strains of this nasty little bugger, before it gets chance to evolve. Difficult to do.A relief to hear that current mutations aren’t able to evade the antibodies induced by current vaccines.
The COVID-19 vaccine developed by Pfizer and BioNTech is likely to protect against a more infectious variant of the virus discovered in Britain which has spread around the world, according to results of further lab tests released on Wednesday.www.reuters.com
That’s good news. I would suggest it is a matter of time before it becomes something that can evade current vaccines. But if we can get vaccines distributed fast enough, maybe we can “end its line” and eliminate the current strains of this nasty little bugger, before it gets chance to evolve. Difficult to do.
We agree about most of it, but simply put the action we take isn’t enough. It still isn’t. New variants are arising and we aren’t taking the action to close them down.I also recon its a matter of WHEN not if the next mutation will appear that totally side steps all current vaccines + past exposure protection.
IF by chance the mutation is also associated with worse outcomes or the same the entire world would be back to Dec 2019 all over again.......So what do we do than? Accept life expectancy will now be closer to 70 something rather than 80 something, and even at 50 you're chance of death isn't insignificant?
Given the way us humans behave I cannot see a global vaccine program eliminating this virus like small pox. If anything the patchy vaccination roll out mighty simply increase the mutation rate as it introduces a new selective pressure.
This statement might seem a bit weird, given the losses, but we aren’t serious enough about it. If we treated Ebola outbreaks like this, it would be in the UK. Track, trace, isolate, inoculate. The system we have is a joke.
The policy we have for vaccinating the vulnerable sounds nice, but it isn't the fastest way of stopping the spread. The best way to do that would be vaccinate the “front line“ as fast as possible, and anyone who really needed to travel (e.g. the wagon drivers bringing your food into the country).
I’ve said before in these threads, that it’s possible but we won’t achieve it. We need global leadership and coordination in a manner that no longer exists.
A cluster of viral mutations seems to be speeding the spread of COVID-19—and scientists are racing to understand how they work.www.nationalgeographic.com
It's odd isn't it.South Africa has reopened its major land borders with neighboring countries after closing them last month to prevent the spread of the COVID-19 virusabcnews.go.com
It's odd isn't it.
It's happening all over the world, in many places where lockdowns either aren't in place or aren't very restrictive at all.
Don't misunderstand me I'm not a lock-down sceptic or advocating for dropping restrictions here in the uk.
But it just shows how very little we understand how it spreads at the population level. Even if the underlying principles are known.
Professor Graeme Meintjes, second chair in the Department of Medicine at UCT, lead of CIDRI-Africa’s Clinical Platform and a co-investigator on the trial, said: “Vaccines currently being administered internationally are designed to generate immunity against the SARS-CoV-2 spike protein alone.
’’As already witnessed, the spike protein is mutation-prone, with variants 501Y.V2 and B.1.1.7 in this spike protein leading to higher transmissibility, increasing the urgency for a broader range of effective and safe Covid-19 vaccines to be available to the global population.
’’There is also now evidence for certain vaccines that protection against the 501Y.V2 variant is reduced. In light of this, we will likely need alternative or adapted vaccines that are safe and effective against all current and future variants.
“An additional protein in the SARS-CoV-2 virus is the nucleocapsid protein. The nucleocapsid protein appears to be much more stable over time and therefore has a lower risk of developing mutations that could risk vaccine failure.
Dr Patrick Soon-Shiong, said: “We are excited about the potential of our COVID-19 vaccine candidate, especially how it could solve the growing problem of new variants of the virus that have begun to appear. We are seeing these mutations around the world, causing serious outbreaks already in the United Kingdom and in my native South Africa. The mutations are occurring on the spike protein of the virus, which is why it’s vital to pursue a vaccine that does not rely solely on targeting the spike protein. Unlike those antibody-based vaccines, our T-cell-based vaccine candidate is intended to kill the infected cell to prevent the virus from replicating and could provide long-term memory to recipients that would not be affected by spike protein mutations.
That’s interesting stuff. There is good reason for targeting the spike proteins though, as I understand it that‘s the best shot at creating antibodies that neutralise the virion. Targeting the virion body might be different.The need for alternative or adapted vaccines that are safe and effective against all current and future variants will see UCT researchers commence the phase one clinical trial of the Covid-19 vaccine candidate, hAd5 T-cell.www.iol.co.za
UCT researchers are expected to start the Phase 1 clinical trial of the hAd5 T-cell COVID-19 vaccine candidate this month.www.news.uct.ac.za
That’s interesting stuff. There is good reason for targeting the spike proteins though, as I understand it that‘s the best shot at creating antibodies that neutralise the virion. Targeting the virion body might be different.
As for targeting vaccines to different blood cells, I’m officially out of my depth. How we expect to second guess immune cell workings, I’ve no idea. Some reading to do.