"The overall nature of Borderlands 2 seems to be an ill-fitting match for the Vita given that it is mainly a twitch shooter."
It's not a twitch shooter, it's not even close to being one, nor is it trying to be. The main draw of the game for hardcore players who put hundreds of hours into it is finding loot, farming for loot and upgrading characters. All of which makes it perfect for a handheld.