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A lot would depend on your other AV equipment. However, I have an LCD TV, surround sound amp, Telewest TV Drive, dvd player, vhs recorder, Xbox 360, and my pc runs MCE.
I would point out that I only use Media Centre streamed to the Xbox 360, so don't have a need to control any pc functions.
To control all this I use the Harmony 360, which is automatically configured for the Xbox 360, but only available from the US. However it controls all my equipment faultlessly, and was simple to set up.
To be honest I think you could use any of the Harmony remotes with a Media Center. The Harmony website has a "Media Center PC" as one of the devices you can add to your remote and it has a full set of Media Center remote commands - so you can add a Media Center device to any Harmony remote and have full Media Center functionality. This means your only real decision is choosing the remote that best suits you in terms of functionality, design and price.
I have a Harmony 885 and use that to control Media Center and it works flawlessly. Originally when I added the Media Center device the "Green Button" on the Media Center remote was mapped to a button on the Harmony LCD screen but I removed that and made the "Menu" button on the remote my "Green Button".