Right, i've been a bit of a fool. in my rush i failed to back up my reg before i edited it, DOH!
MY MCE remote worked fine with S1 suspend in and out using the remote all fine. so i decided to try to make this all work for S3.
Set it to S3 in bios with usb wake-up enabled, and wow, so quite. But the remote wouldn't bring it back out of S3. I tried the Regedit as discused in other threads and now have a problem.
The remote will send the pc to S3 fine but still not bring it back. if i bring it back by using the power button on the case i get a nasty series of beebs (a mix between the error one and a sucess one - the tones you get if you unplug a device or plug 1 in) The mouse does not work untill after this series of beeps ends, about 10 seconds. The remote does still work straight out of S3 though.
Is it possible to "just delete" the new usb entry i made to the reg?
EDIT: The PC also brings it's self straight out of stand-by on it's own now too.