I've got the same problem on Vista. Been messing about with it for hours tonight

.
I've downloaded the latest Sync software (v2.0.4) and installed (with no other programs running and disabled the 'Computer & Files', 'Internet & Network' & 'Email & IM' protection features in McAfee).
I've also ensured that the phone setting for USB debugging is set to on.
I do not know what else to do to get this up and running as I am desperate to upload the new ROM!!!
Have mailed HTC so will report back IF I hear anything...