The PXC450s are indeed bass-light when the noise cancelling circuitry is on. Turn it off, though, and you will be in a world of bass and indeed sub-bass nirvana. In fact, its a little too much.
Do you wear glasses? The 450s don't seal well around my spectacle arms but this break is enough to tame the slight over exuberant bass response.
Tight they most definitely are. Lacking depth, yes only when using the noise cancelling. They easily reach to 18hz (measured by graphing the input source on a PC) so depth is not an issue without noise cancelling enabled.
You should find them very smooth in the treble compared to the HD25s. I posted a detailed review of them against the Bose QC2s
here
Whilst they would probably benefit from a headphone amp, I've never felt the need. They mostly benefit from turning the bass down on the source when not using NC!