Generally, using two drivers will increase output of the sub by upto +6db, pretty much the same as just having 2 single driver subs. The disadvantage of that is you cant split them up if you want to get the best from room eq'ing, but not everyone is that anal anyway

Its worth knowing though that 2 10" drivers are only just more than a single 12", and cant match a single 15" driver for displacement of air. Also, its not possible to force a driver of a given size to go lower without more excursion, which means you get ever closer to the point at which the driver will distort. Basically, multiple drivers will give added volume for each added driver, but not added depth. For that only a larger driver will do.
In general terms, how high a frequency your sub reaches is a moot point, as all will reach above the 80hz generally considered the limit for sub bass. So unless you want an unusual crossover you dont need to worry about your subs upper limit really. Depth is important. Larger boxes go deeper with less effort, but again there are other factors that must be considered so you cant just get any driver and stick it in a huge box for mega depth.
There are 3 main factors that come in to play when considering a sub. Size, price and performance. You can only choose 2 and will have to take a hit on the other at some point.
Power handling is a moot point really in relation to box size. Your driver will have a limit it can handle, and power doesnt always dictate how much excursion your driver will have to deal with, box size will affect this as well. These are things you need to keep an eye on when designing your sub really, and simulation software really is there to remove the need to build several boxes and designs to find which will work best.
Generally speaking though, the larger you build the easier it will be to get more performance, or rather depth out of the box. The more compact the sub the more difficult, and this is where the price comes in. It is possible to get smaller boxes to perform beyond what they really should, but it starts to cost a lot and get more difficult.
DF and FF subs are really a matter of choice. Some say that a DF model will suffer from driver sag over time, but Ive yet to come across someone really concerned with that, certainly the manufacturers arent. As for Isobaric designs, they are the best way to get a smaller box to outperform its physical limits. The problem with these is your paying for an extra driver and gaining no extra output volume wise and you need twice the amp power because you have twice the drivers. Isobaric does however make sure the drivers are very accurate and its said that this design will give the best bass from a small box. Due to cost, and the fact large boxes will go deeper for much less money, its a design people dont seem to bother with.
For more info on sub types see
here.