If a heavy bag and swapping lenses is doing your nut in that much, then maybe it's for you, but there's no way I'd be getting rid of a 17-50 2.8 and a 70-200 (f4
or f2.8) to use a 18-270. If I could afford to have one aswell, maybe, but not instead. The image quality will likely not be as good and if nowt else, you're losing a fair amount of maximum aperture.
As for it replacing your 10-20 as well, I assume that's just cause you're not using it?

Horses for courses though. No point in having 2-3 good lenses if the logistics of using them is actually stopping you going out and taking photos.