You often hear of people saying that a power amp is less of an upgrade than a Pre-amp but if you are coming from a Receiver to a Pre-amp (probably the most common route) then that jump will be big. I imagine if you ask someone who has had a few amps and Pre-amps they might have a different view?
Personally I have found quite big differences between amps, Arcam and Parasound for instance are almost polar extremes in terms of the sound and this was when I hung my amps off an Onkyo 875.
My experience with Pre-amps isn't quite as extensive but I would probably say the differences are broadly similar to those you can get with Amps.
In terms of the chain I would agree that in general terms a balance is ideal however I don't completely agree with the 'garbage in/garbage out' soundbite you often hear quoted. If you look at relative distortion figures then the opposite is more likely true; the room can be orders of magnitude worse than the speakers and they are still very much worse than the amp, Pre-amp & source.
If you look at my system though you could point out the relatively cheap sources I use and cheap speakers but like most it is a work in progress but I do feel sources have matured a lot and the jump in quality doesn't necessarily correspond with the jump in price, I also couldn't take a backwards step in functionality and UI with say a Bryston BDP-1 over my Squeezebox, or some exotic BD player over my Popcorn Hour that is not to say I don't covet improving those sources but bar the SB Transporter there isn't much at sensible money that wouldn't compromise me elsewhere.
I seem to be rambling but I guess my point was that amps can be far from a minor upgrade in some systems and any disproportionate purchase should not necessarily be interpreted as the system endgame. This is especially true whilst Bob has these magnificent Amps at such a crazy price, who can be blamed for investing in something that might seem over the top right now, we all have dreams of what our systems will be someday, right?
Adam