Evening GUI,
Mmm? lots to think about.
I guess what you really need to do is answer a few critical questions like:
Q: Is this system going to be mainly for music, films/TV or games? (Perhaps an equal measure of all, i.e 33% for each)
Q: What is the absolute maximum budget (This always goes up

)
Q: How much space am I prepared to give to this potential system? (Floorstanders, standmounts or wall-mounted satellites speakers for example)
Once you've got these type of things straight in your mind I think you should be able to rule some kit out, like using a stereo amp in conjunction with an AV Amp perhaps. It may well be that you are happy with just using a stereo amp as music is far more important and you're not bothered about true 5.1 decoding/processing?
Personally I wanted one box (Amp) to be reasonably good at it all and I didn't want another box (Stereo Amp) cluttering up my Av stand so I broke the bank and bought a Yamaha Z7
Optical connection is pretty much a must if say for example you want to get the best (5.1) from your Sky box, not even SKY HD does DD over HDMI, it has to be optical.
I know next to nothing compared to most of the good folk on these forums, so I advise you get some more input on here if you can. I've never heard of the Audio-M range, do you mean
these? If so my advice would be to audition them first if at all possible. Are you based in the US? If so then check them out, if you're from the UK I would avoid getting speakers from so far away, if they go wrong repairs could be a logistical nightmare.
Hope all this helps; good luck and have fun shopping
D